Sweet’s syndrome — also known as acute
febrile neutrophilic dermatosis — is a rare skin condition marked by fever and
painful skin lesions that appear mainly on your arms, neck, face and back. The
exact cause of Sweet’s syndrome isn’t always known. In some people, it’s
triggered by an infection, illness or certain medications. Sweet’s syndrome can
also occur with some types of cancer. Signs and symptoms often disappear just a
few days after treatment begins, but recurrence is common.
Symptoms
Sweet’s syndrome is marked by an abrupt
eruption of small red bumps on your arms, neck, face or back — often after a
fever or upper respiratory infection. The bumps grow quickly in size, spreading
into painful clusters up to an inch or so in diameter.
When to see a doctor
If you develop a painful, red rash that
quickly grows in size, see your doctor for appropriate treatment.
Causes
In most cases, the cause of Sweet’s
syndrome isn’t known. Sweet’s syndrome is sometimes associated with cancer,
most often leukemia. A few cases may be associated with a solid tumor, such as
chest or colon cancer. Sweet’s syndrome may also occur as a reaction to a
medication — most commonly a type of drug that boosts production of white blood
cells.
Complication
There is a risk of the skin lesions
becoming infected. Follow your doctor’s recommendations for caring for the
affected skin. In cases where Sweet’s syndrome is associated with cancer, the
eruptions of the lesions may be the first sign of cancer either appearing or
recurring.
In some cases, Sweet’s syndrome resolves
without treatment. But medications can speed the process dramatically. The most
common medications used for Sweet’s syndrome are corticosteroids, which come in
a variety of forms, including:
Pills. Oral corticosteroids, such as
prednisone, work very well but will affect your entire body. Long-term use can
cause weight gain and weakened bones.
Creams or ointments. These preparations
usually affect just the portion of skin where they’re applied, but can cause
thinning skin.
Injections. Another option is to inject a
small amount of corticosteroid right into each lesion. This may be less
feasible for people who have a great number of lesions.
To avoid the side effects associated with
long-term corticosteroid use, your doctor may suggest other types of oral
medications.
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